Financial Secretary Paul Chan will visit Wuhan, Changsha and Zhengzhou from August 21 to 24.
In Wuhan he will open the roving exhibition on the Hong Kong Special Administrative Region's 20th anniversary.
He will then go to Changsha and Zhengzhou to attend gala dinners to celebrate the opening of the Hunan and Henan liaison units of the HKSAR Government.
Mr Chan will meet senior officials of Hubei, Hunan and Henan provinces to strengthen trade and economic ties.
He will also visit Hong Kong enterprises and key developments in the three cities and meet Hong Kong people working and doing business there.
Secretary for Financial Services & the Treasury James Lau will be Acting Financial Secretary during Mr Chan's absence.