Chief Executive Carrie Lam will visit Myanmar from September 14 to 16.
She will speak at the 14th World Chinese Entrepreneurs Convention in Yangon.
The biennial conference provides a platform for Chinese entrepreneurs and business and industrial leaders from around the world to enhance economic co-operation and understanding.
She will also meet senior Burmese officials in Naypyidaw.
Chief Secretary Matthew Cheung will be Acting Chief Executive during Mrs Lam's absence.
