Permanent Secretary for Food & Health Marion Lai and Permanent Secretary for Education Cherry Tse will swap posts from January 19.
Deputy Commissioner of Correctional Services Yau Chi-chiu will succeed Sin Yat-kin as Commissioner on December 26.
Secretary for the Civil Service Paul Tang said the two permanent secretaries are seasoned Administrative Officers with rich experience in public administration and proven leadership and management skills.
He said Mr Yau has proven leadership and administrative skills, profound professional knowledge and extensive operational experience.